| Bundesliga | Werder Bremen | FSV Mainz 05 | 15‑Mar | 0-2 | |
| UEFA Europa Conference League | Sigma Olomouc | FSV Mainz 05 | 12‑Mar | 0-0 | |
| Bundesliga | FSV Mainz 05 | VfB Stuttgart | 07‑Mar | 2-2 | |
| Bundesliga | Bayer Leverkusen | FSV Mainz 05 | 28‑Feb | 1-1 | |
| Bundesliga | FSV Mainz 05 | Hamburger SV | 20‑Feb | 1-1 | |
| Bundesliga | Borussia Dortmund | FSV Mainz 05 | 13‑Feb | 4-0 | |
| Bundesliga | FSV Mainz 05 | FC Augsburg | 07‑Feb | 2-0 | |
| Bundesliga | RB Leipzig | FSV Mainz 05 | 31‑Jan | 1-2 | |
| Bundesliga | FSV Mainz 05 | VfL Wolfsburg | 24‑Jan | 3-1 | |
| Bundesliga | 1. FC Köln | FSV Mainz 05 | 17‑Jan | 2-1 | |
| Bundesliga | FSV Mainz 05 | 1. FC Heidenheim | 13‑Jan | 2-1 | |
| Bundesliga | Union Berlin | FSV Mainz 05 | 10‑Jan | 2-2 | |
| Bundesliga | FSV Mainz 05 | FC St. Pauli | 21‑Dec | 0-0 | |
| UEFA Europa Conference League | FSV Mainz 05 | Samsunspor | 18‑Dec | 2-0 | |
| Bundesliga | Bayern München | FSV Mainz 05 | 14‑Dec | 2-2 | |
| UEFA Europa Conference League | Lech Poznan | FSV Mainz 05 | 11‑Dec | 1-1 | |
| Bundesliga | FSV Mainz 05 | Borussia Mönchengladbach | 05‑Dec | 0-1 | |
| Bundesliga | SC Freiburg | FSV Mainz 05 | 30‑Nov | 4-0 | |
| UEFA Europa Conference League | Universitatea Craiova | FSV Mainz 05 | 27‑Nov | 1-0 | |
| Bundesliga | FSV Mainz 05 | 1899 Hoffenheim | 21‑Nov | 1-1 | |
| Bundesliga | Eintracht Frankfurt | FSV Mainz 05 | 09‑Nov | 1-0 | |
| UEFA Europa Conference League | FSV Mainz 05 | Fiorentina | 06‑Nov | 2-1 | |
| Bundesliga | FSV Mainz 05 | Werder Bremen | 01‑Nov | 1-1 | |
| DFB Pokal | FSV Mainz 05 | VfB Stuttgart | 29‑Oct | 0-2 | |
| Bundesliga | VfB Stuttgart | FSV Mainz 05 | 26‑Oct | 2-1 | |
| UEFA Europa Conference League | FSV Mainz 05 | Zrinjski | 23‑Oct | 1-0 | |
| Bundesliga | FSV Mainz 05 | Bayer Leverkusen | 18‑Oct | 3-4 | |
| Bundesliga | Hamburger SV | FSV Mainz 05 | 05‑Oct | 4-0 | |
| UEFA Europa Conference League | Omonia Nicosia | FSV Mainz 05 | 02‑Oct | 0-1 | |
| Bundesliga | FSV Mainz 05 | Borussia Dortmund | 27‑Sep | 0-2 | |
| Bundesliga | FC Augsburg | FSV Mainz 05 | 20‑Sep | 1-4 | |
| Bundesliga | FSV Mainz 05 | RB Leipzig | 13‑Sep | 0-1 | |
| Bundesliga | VfL Wolfsburg | FSV Mainz 05 | 31‑Aug | 1-1 | |
| UEFA Europa Conference League | FSV Mainz 05 | Rosenborg | 28‑Aug | 4-1 | |
| Bundesliga | FSV Mainz 05 | 1. FC Köln | 24‑Aug | 0-1 | |
| UEFA Europa Conference League | Rosenborg | FSV Mainz 05 | 21‑Aug | 2-1 | |
| DFB Pokal | Dynamo Dresden | FSV Mainz 05 | 18‑Aug | 0-1 | |
| Friendlies Clubs | FSV Mainz 05 | Strasbourg | 09‑Aug | 0-0 | |
| Friendlies Clubs | FC Saarbrücken | FSV Mainz 05 | 16‑Jul | 1-4 | |
| Friendlies Clubs | Bayern Alzenau | FSV Mainz 05 | 11‑Jul | 0-4 | |
