| Home Team | Away Team | Match Date | Score | Stats |
|---|---|---|---|---|
| Hibernians | Balzan FC | 01‑May | 2-2 | |
| Hamrun Spartans | Gudja United | 22‑Apr | 2-0 | |
| Balzan FC | Birkirkara | 21‑Apr | 2-1 | |
| Mosta | Santa Lucía | 21‑Apr | 2-1 | |
| Gzira United | Zebbug Rangers | 21‑Apr | 4-0 | |
| Floriana | Hibernians | 21‑Apr | 2-5 | |
| Valletta FC | Marsaxlokk | 20‑Apr | 1-1 | |
| Sirens | Pietà Hotspurs | 20‑Apr | 0-0 | |
| Balzan FC | Gzira United | 15‑Apr | 0-2 | |
| Zebbug Rangers | Mosta | 15‑Apr | 0-5 | |
| Santa Lucía | Hamrun Spartans | 15‑Apr | 1-1 | |
| Hibernians | Sirens | 15‑Apr | 1-1 | |
| Gudja United | Valletta FC | 14‑Apr | 1-2 | |
| Birkirkara | Pietà Hotspurs | 14‑Apr | 3-2 | |
| Marsaxlokk | Floriana | 14‑Apr | 1-5 | |
| Hamrun Spartans | Zebbug Rangers | 10‑Apr | 4-0 | |
| Valletta FC | Santa Lucía | 10‑Apr | 0-1 | |
| Mosta | Balzan FC | 10‑Apr | 2-3 | |
| Pietà Hotspurs | Hibernians | 08‑Apr | 1-4 | |
| Sirens | Marsaxlokk | 08‑Apr | 3-2 | |
| Gzira United | Birkirkara | 08‑Apr | 1-3 | |
| Floriana | Gudja United | 08‑Apr | 1-1 | |
| Birkirkara | Hibernians | 02‑Apr | 5-0 | |
| Santa Lucía | Floriana | 02‑Apr | 0-2 | |
| Marsaxlokk | Pietà Hotspurs | 02‑Apr | 1-2 | |
| Balzan FC | Hamrun Spartans | 01‑Apr | 0-4 | |
| Zebbug Rangers | Valletta FC | 01‑Apr | 1-5 | |
| Gudja United | Sirens | 01‑Apr | 0-1 | |
| Gzira United | Mosta | 01‑Apr | 1-2 | |
| Sirens | Santa Lucía | 12‑Mar | 2-1 |
Malta Premier League 2022