| U18 Premier League - South | West Ham United U18 | Home | 05‑Sep 12:00 | |
| U18 Premier League - South | Brentford U18 | Home | 12‑Sep 11:00 | |
| U18 Premier League - South | Chelsea U18 | Away | 19‑Sep 11:30 | |
| U18 Premier League - South | Norwich City U18 | Home | 17‑Oct 11:00 | |
| U18 Premier League - South | Birmingham City U18 | Away | 24‑Oct 11:00 | |
| U18 Premier League - South | Tottenham Hotspur U18 | Home | 31‑Oct 12:00 | |
| U18 Premier League - South | Southampton U18 | Away | 03‑Nov 11:00 | |
| U18 Premier League - South | Crystal Palace U18 | Home | 21‑Nov 12:00 | |
| U18 Premier League - South | Arsenal U18 | Away | 28‑Nov 12:00 | |
| U18 Premier League - South | West Bromwich Albion U18 | Home | 12‑Dec 11:00 | |
| U18 Premier League - South | Reading U18 | Away | 19‑Dec 11:00 | |
| U18 Premier League - South | Brighton U18 | Away | 16‑Jan 11:30 | |
| U18 Premier League - South | Ipswich Town U18 | Home | 23‑Jan 11:00 | |
| U18 Premier League - South | West Ham United U18 | Away | 30‑Jan 11:00 | |
| U18 Premier League - South | Aston Villa U18 | Home | 06‑Feb 12:30 | |
| U18 Premier League - South | Brentford U18 | Away | 13‑Feb 11:30 | |
| U18 Premier League - South | Chelsea U18 | Home | 20‑Feb 11:30 | |
| U18 Premier League - South | Norwich City U18 | Away | 27‑Feb 11:00 | |
| U18 Premier League - South | Birmingham City U18 | Home | 06‑Mar 12:00 | |
| U18 Premier League - South | Tottenham Hotspur U18 | Away | 13‑Mar 12:00 | |
| U18 Premier League - South | Crystal Palace U18 | Away | 20‑Mar 12:00 | |
| U18 Premier League - South | Fulham U18 | Home | 03‑Apr 11:00 | |
| U18 Premier League - South | Southampton U18 | Home | 10‑Apr 11:00 | |
| U18 Premier League - South | West Bromwich Albion U18 | Away | 17‑Apr 11:00 | |
| U18 Premier League - South | Arsenal U18 | Home | 24‑Apr 12:00 | |
| U18 Premier League - South | Reading U18 | Home | 01‑May 11:00 | |
| U18 Premier League - South | Fulham U18 | Away | 08‑May 11:00 | |
